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Li Y. [6]
Wang Y. [2]
Abriata L.... [1]
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文献类型
期刊论文 [6]
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2020 [6]
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英语 [6]
来源机构
Science [6]
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文献类型:期刊论文
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来源机构:Science
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Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
期刊论文
, 2020, 卷号: 368, 期号: 6497
作者:
Dai W.
;
Zhang B.
;
Jiang X.-M.
;
Su H.
;
Li J.
;
Zhao Y.
;
Xie X.
;
Jin Z.
;
Peng J.
;
Liu F.
;
Li C.
;
Li Y.
;
Bai F.
;
Wang H.
;
Cheng X.
;
Cen X.
;
Hu S.
;
Yang X.
;
Wang J.
;
Liu X.
;
Xiao G.
;
Jiang H.
;
Rao Z.
;
Zhang L.-K.
;
Xu Y.
;
Yang H.
;
Liu H.
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/07/28
aldehyde
antimicrobial activity
drug
enzyme activity
infectivity
inhibitor
reaction kinetics
viral disease
Coronavirus
SARS coronavirus
3C-like proteinase, Coronavirus
antivirus agent
cysteine proteinase
viral protein
animal
Betacoronavirus
chemical structure
chemistry
Chlorocebus aethiops
Coronavirus infection
dog
drug design
drug effect
enzyme active site
enzymology
female
human
male
mouse
pandemic
preclinical study
protein tertiary structure
Sprague Dawley rat
toxicity testing
Vero cell line
virus pneumonia
Animals
Antiviral Agents
Betacoronavirus
Catalytic Domain
Chlorocebus aethiops
Coronavirus Infections
Cysteine Endopeptidases
Dogs
Drug Design
Drug Evaluation, Preclinical
Female
Humans
Male
Mice
Molecular Structure
Pandemics
Pneumonia, Viral
Protein Structure, Tertiary
Rats, Sprague-Dawley
Toxicity Tests
Vero Cells
Viral Nonstructural Proteins
De novo protein design enables the precise induction of RSV-neutralizing antibodies
期刊论文
, 2020, 卷号: 368, 期号: 6492
作者:
Sesterhenn F.
;
Yang C.
;
Bonet J.
;
Cramer J.T.
;
Wen X.
;
Wang Y.
;
Chiang C.-I.
;
Abriata L.A.
;
Kucharska I.
;
Castoro G.
;
Vollers S.S.
;
Galloux M.
;
Dheilly E.
;
Rosset S.
;
Corthésy P.
;
Georgeon S.
;
Villard M.
;
Richard C.-A.
;
Descamps D.
;
Delgado T.
;
Oricchio E.
;
Rameix-Welti M.-A.
;
Más V.
;
Ervin S.
;
Eléouët J.-F.
;
Riffault S.
;
Bates J.T.
;
Julien J.-P.
;
Li Y.
;
Jardetzky T.
;
Krey T.
;
Correia B.E.
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2020/07/28
algorithm
antibody
design
neutralization
protein
vaccine
Mus
Primates
Respiratory syncytial virus
Rice stripe virus
epitope
fusion protein
nanobody
neutralizing antibody
respiratory syncytial virus vaccine
biology
biosynthesis
chemistry
human
Human respiratory syncytial virus
immunology
procedures
protein conformation
protein engineering
protein motif
Amino Acid Motifs
Antibodies, Neutralizing
Computational Biology
Humans
Immunodominant Epitopes
Protein Conformation
Protein Engineering
Recombinant Fusion Proteins
Respiratory Syncytial Virus Vaccines
Respiratory Syncytial Virus, Human
Single-Domain Antibodies
An investigation of transmission control measures during the first 50 days of the COVID-19 epidemic in China
期刊论文
, 2020, 卷号: 368, 期号: 6491
作者:
Tian H.
;
Liu Y.
;
Li Y.
;
Wu C.-H.
;
Chen B.
;
Kraemer M.U.G.
;
Li B.
;
Cai J.
;
Xu B.
;
Yang Q.
;
Wang B.
;
Yang P.
;
Cui Y.
;
Song Y.
;
Zheng P.
;
Wang Q.
;
Bjornstad O.N.
;
Yang R.
;
Grenfell B.T.
;
Pybus O.G.
;
Dye C.
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/07/28
data set
disease control
disease incidence
disease transmission
epidemic
public health
viral disease
Article
China
coronavirus disease 2019
disease duration
disease transmission
epidemic
health care planning
human
incidence
infection control
influenza A (H1N1)
pandemic
patient isolation
priority journal
public health
sample size
scale up
traffic and transport
Betacoronavirus
communicable disease control
Coronavirus infection
epidemic
pandemic
public health service
regression analysis
statistical model
travel
virus pneumonia
China
Hubei
Wuhan
Coronavirus
Betacoronavirus
China
Communicable Disease Control
Coronavirus Infections
Epidemics
Humans
Incidence
Models, Statistical
Pandemics
Pneumonia, Viral
Public Health Practice
Regression Analysis
Travel
Structural insights into immunoglobulin M
期刊论文
, 2020, 卷号: 367, 期号: 6481
作者:
Li Y.
;
Wang G.
;
Li N.
;
Wang Y.
;
Zhu Q.
;
Chu H.
;
Wu W.
;
Tan Y.
;
Yu F.
;
Su X.-D.
;
Gao N.
;
Xiao J.
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/07/28
immunoglobulin M
secretory component
antibody
immunity
molecular analysis
polymer
protein
Article
binding site
conformational transition
cryoelectron microscopy
crystal structure
human
hydrophobicity
nonhuman
oligomerization
priority journal
protein assembly
protein domain
protein function
protein interaction
protein stability
protein structure
protein transport
surface area
One-dimensional van der Waals heterostructures
期刊论文
, 2020, 卷号: 367, 期号: 6477
作者:
Xiang R.
;
Inoue T.
;
Zheng Y.
;
Kumamoto A.
;
Qian Y.
;
Sato Y.
;
Liu M.
;
Tang D.
;
Gokhale D.
;
Guo J.
;
Hisama K.
;
Yotsumoto S.
;
Ogamoto T.
;
Arai H.
;
Kobayashi Y.
;
Zhang H.
;
Hou B.
;
Anisimov A.
;
Maruyama M.
;
Miyata Y.
;
Okada S.
;
Chiashi S.
;
Li Y.
;
Kong J.
;
Kauppinen E.I.
;
Ikuhara Y.
;
Suenaga K.
;
Maruyama S.
收藏
  |  
浏览/下载:104/0
  |  
提交时间:2020/07/28
boron nitride
inorganic salt
molybdenum disulfide
single walled nanotube
unclassified drug
chemical bonding
experimental study
nanotube
one-dimensional modeling
ultrastructure
Article
chemical structure
crystal
one dimensional van der Waals heterostructure
particle size
priority journal
Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2
期刊论文
, 2020, 卷号: 367, 期号: 6485
作者:
Yan R.
;
Zhang Y.
;
Li Y.
;
Xia L.
;
Guo Y.
;
Zhou Q.
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/07/28
angiotensin converting enzyme 2
coronavirus spike glycoprotein
heterodimer
homodimer
amino acid transporter
angiotensin converting enzyme 2
dipeptidyl carboxypeptidase
protein binding
SLC6A19 protein, human
spike protein, SARS-CoV-2
virus receptor
enzyme
gene
gene expression
protein
ultrastructure
virus
Article
binding site
complex formation
controlled study
coronavirus disease 2019
cryoelectron microscopy
dimerization
embryo
enzyme structure
human
human cell
nonhuman
priority journal
protein domain
SARS-related coronavirus
Severe acute respiratory syndrome coronavirus 2
amino acid sequence
Betacoronavirus
Coronavirus infection
molecular model
pandemic
protein multimerization
SARS coronavirus
sequence alignment
ultrastructure
virus pneumonia
Coronavirus
SARS coronavirus
Amino Acid Sequence
Amino Acid Transport Systems, Neutral
Betacoronavirus
Coronavirus Infections
Cryoelectron Microscopy
Humans
Models, Molecular
Pandemics
Peptidyl-Dipeptidase A
Pneumonia, Viral
Protein Binding
Protein Domains
Protein Multimerization
Receptors, Virus
SARS Virus
Sequence Alignment
Spike Glycoprotein, Coronavirus